Trends in 5-year Relative Survival Rates for Intrahepatic Cholangiocarcinoma in the US

Abstract

Introduction: Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer with increasing incidence rates. The purpose of this study is to investigate the impact of sex, and race/ethnicity on the 5-year relative survival rate for individuals above the age of 20 using the Surveillance, Epidemiology, and End Results (SEER) database from 1992-2011. Methods: Patients diagnosed with ICC from 1992-2011 were identified from the SEER Registry. The 5-year relative survival rates of ICC in the US were calculated during different time intervals consisting of 1992-1996, 1997-2001, 2002-2006, and 2007-2011. The ethnic groups used in this analysis consisted of black, white, and other where “other” included American Indians, Alaskans and Asian/Pacific Islanders. Results: Black men had the highest 5-year relative survival rate at 11.9% from 2007-2011. The 5-year relative survival rate was 5.50% and 6.1% for white men and men denoted in the other category, respectively from 2007-2011. The 5-year relative survival rate has decreased from 2002-2006 to 2007-2011 for white men and “other” men, however it has increased for black men. In 2002-2006, the 5-year relative survival rate was 6.60% for white men, and 8.3% for “other” men. In 2007-2011, the 5-year survival rate was 5.50% for white men, and 6.1% for “other” men. White men had the lowest 5-year relative survival rate amongst all ethnic groups. For women, the 5-year survival rate is highest for black women at 10.8% from 2007-2011. The 5-year survival rate has increased over the years from 1992-2011 for most ethnic groups when comparing women. There was a decrease in 5-year relative survival rate of 11.40% to 10.60% from 2002-2006 and 2007-2011 for “other” women. White women had the lowest 5-year relative survival rate from 2002-2011 in comparison to other ethnic groups. Women, in comparison to men had higher 1, 2, 3, 4, and 5-year relative survival rates from 2002-2011 when compared to rates from 1992-2001. Conclusion: This study shows the impact of race/ethnicity and gender on 5-year relative survival rates for ICC. Women had higher 1, 2, 3, 4, and 5-year survival rates than men, which may suggest that women seek medical attention earlier. The 5-year survival rate is also higher for African men and women. This may support interventions to inform certain ethnic groups about the importance of screening for infections such as Hepatitis B and C and seek medical attention earlier.