Trends, characteristics, and incidence of anaphylaxis in 2001-2010: A population-based study

Abstract

Anaphylaxis is a potentially life-threatening systemic allergic reaction. We aimed to determine the incidence rate and causes of anaphylaxis during a 10-year period in Olmsted County, Minnesota. Using the resources of the Rochester Epidemiology Project, a comprehensive records linkage system, we performed a population-based incidence study in Olmsted County, Minnesota, from 2001 through 2010. All cases with a diagnosis of anaphylactic shock and 20% of cases with related diagnoses were manually reviewed. The relationships of age group, sex, and year of anaphylaxis with incidence rates were assessed by fitting Poisson regression models. Six hundred thirty-one cases of anaphylaxis were identified. The median age was 31years (interquartile range, 19-44years). The overall age- and sex-adjusted incidence rate was 42 (95% CI, 38.7-45.3) per 100,000 person-years. There was a significant increase in the overall incidence of anaphylaxis during the study period, with an average increase of 4.3% per year (P<.001). In addition, there was a 9.8% increase per year in the incidence rate of food-related anaphylaxis. Food-related anaphylaxis was most common in children aged 0 to 9years, venom-related anaphylaxis was most common in those 20 to 39years of age, and medication-related anaphylaxis was most common in those 30 to 39years of age. The overall incidence rate of anaphylaxis was 42 per 100,000 person-years from 2001-2010 in Olmsted County, Minnesota. The incidence of anaphylaxis increased over time,and several inciting triggers were uniquely associated withdifferent age groups.