Abstract

Background: Monitoring treatment outcomes and understanding the reasons for unsuccessful treatment have paramount importance for the tuberculosis control program. This study was designed to evaluate trends and treatment outcomes of tuberculosis patients at the Tepi Health Center and to identify the predictors of unsuccessful treatment outcome.Method: Retrospective review of TB cases, registered in the Tepi health center from 2011-2018, was conducted using data, extracted from medical records of TB patients. The structured data extraction form was prepared and used to extract socio-demographic, clinical and outcome data of study cases. The case definition and the treatment outcome of patients were ascertained and reported in accordance with the World Health Organization guideline. A binary logistic regression model was fit to identify predictors of unsuccessful outcome.Results: A total of 1651 TB patients, registered at the Tepi Public Health Center in between June 2011 and May 2018, were included in the study. Of all 924(56 %) were males and 1053 (63.8 %) cases were in between the age range of 15 and 35 years. HIV-status of 1019 TB cases was unknown and 189(11.4 %) of participants were HIV-positive. 457 (27.7 %) cases were diagnosed with extra pulmonary TB (EPTB) and 1194(72.3 %) were pulmonary TB patients, out of which 376(73.6 %) were smear-positive pulmonary TB (PTB+). The overall treatment success rate (TSR) of patients was 80.4 % (1327/1651), while it was 84.8 % (134/158), 80.2 % (410/511), and 78.3 % (148/189) among the transfer-in, PTB+, and HIV+ cases, respectively. Higher numbers of successful treatment outcomes were recorded among new (82.7 %) EPTB cases (84.7 %). The cure rate was 73.6 %(376/511) and 18(34/189) among patients with PTB+ and HIV+, respectively. Multiple logistic regression analysis indicated that residence sites (OR .763(.584, .996) and TB/HIV co-infection (OR 0.661(0.444, 0.985), were significantly associated with the treatment outcome. Rural residence was 27.1 % less likely to have successful treatment. There was significant heterogeneity in the odds of having successful treatment outcomes across years of initiating treatment.Conclusion: The treatment success rate among study cases was lower than the WHO’s target and further efforts like availability of TB clinics in nearby sites and reducing rate of HIV infection should be made to improve the rate of successful treatment outcome

Highlights

  • There are Dunnock Prunella modularis (Linnaeus, 1758) nests in the Carpathians and the Crimean Mountains mainly, occasionally in the northern region of Ukrainian Polissia [1]

  • Materials and methods of the research The research were conducted on the territory of National Park “Prypiat-Stokhid” at left bank of the Prypiat River near Svalovychi village in Liubeshiv district, Volyn region of Ukraine (N 51°52' E 25°39') during the part of September until the beginning of the end of 2nd decade of October 2012-2017

  • During the visible autumn migrations, majority of them flew in the morning, in the first 3 hours of observations (75.5–83.5 % of all counted birds in different years, in average 79.6 %)

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Summary

Introduction

There are Dunnock Prunella modularis (Linnaeus, 1758) nests in the Carpathians and the Crimean Mountains mainly, occasionally in the northern region of Ukrainian Polissia [1]. This species is possibly breeding (breeding not confirmed) and was considered rare during migrations in National Park “Prypiat-Stokhid”. The main information about this species was collected during the migration period, in particular during the study of visible autumn migrations of birds This information is necessary for the development and implementation of a management plan in the National Park for a whole complexes of migratory birds and separate species, first of all rare or few numerous

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