Trends and factors of botanical dietary supplement use among US adults with COPD from 1999 to 2016.

Yanjie Sun,Rongying Wang,Chao Li,Nan Huo,Weiwei Tang,Muhammad Adrish

doi:10.1371/journal.pone.0239674

Abstract

The potential effects of botanical dietary supplements (BDS) in the treatment of asthma have been proposed. However, the evidence of the effects of BDS use among patients with COPD is limited. The objective of our study was to exam the trends and effects of BDS use among US adults with COPD. A serial, cross-sectional study was conducted by using data of the NHANSE from 1999 to 2016 (n = 53,348). COPD (n = 2,580) was identified by using self-reported diagnosis history, and any BDS use was identified in the past 30 days. The prevalence of BDS use was calculated for respondents with and without COPD. Simple linear regression models were applied to test for trends in BDS use. Multiple logistic regression models were used to identify the factors of BDS use and patients' clinical outcomes, including all-cause hospitalization and abnormal hemoglobin levels, associated with BDS use. The results were weighted to represent national estimates. The prevalence of BDS use was greater among participants who had COPD compared to the referent group (mean 16.77% vs. 15.11%, p = 0.044). The trend of BDS use decreased from 1999 through 2016 in COPD group (p = 0.0023), but the trend remained stable in the non-COPD group (P>0.05). Results of multivariate logistic regression models showed that patients with higher family income (≥100% FPL) and graduated from college were more likely to use BDS compared with non-users. BDS use was associated with a lower likelihood of having all-cause hospitalization (adjusted odds ratio = 0.64; 95% CI 0.45-0.92) and abnormal levels of hemoglobin (adjusted odds ratio = 0.67; 95% CI 0.49-0.92) among adult COPD patients, after adjusting for covariates. The overall use of BDS decreased during 1999 through 2016 for US adults with COPD. The potential benefit of these supplemental medications use for clinical outcomes might exist for adult COPD patients.

Highlights

Chronic obstructive pulmonary disease (COPD) is a common group of chronic lung conditions with characteristics that are progressive and irreversible airflow obstruction [1]
The prevalence of botanical dietary supplements (BDS) use was greater among participants who had COPD compared to the referent group
Results of multivariate logistic regression models showed that patients with higher family income ( 100% Federal Poverty Level (FPL)) and graduated from college were more likely to use BDS compared with non-users

Summary

Introduction

Chronic obstructive pulmonary disease (COPD) is a common group of chronic lung conditions with characteristics that are progressive and irreversible airflow obstruction [1]. COPD is a worldwide public health condition that usually onsets in middle-aged or elderly persons, especially those with a long history of smoking. Based on the CDC report, more than 10% of the population older than 45 years in the United States has been diagnosed with COPD [2]. As the third leading cause of death in the United States, the mortality from COPD has increased during the past 30 years in both men and women [3]. The evidence of the effects of BDS use among patients with COPD is limited.

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Results

Conclusion