Abstract
Coumarins are naturally occurring molecules with a versatile range of activities. Their structural and physicochemical characteristics make them a privileged scaffold in medicinal chemistry and chemical biology. Many research articles and reviews compile information on this important family of compounds. In this overview, the most recent research papers and reviews from 2020 are organized and analyzed, and a discussion on these data is included. Multiple electronic databases were scanned, including SciFinder, Mendeley, and PubMed, the latter being the main source of information. Particular attention was paid to the potential of coumarins as an important scaffold in drug design, as well as fluorescent probes for decaging of prodrugs, metal detection, and diagnostic purposes. Herein we do an analysis of the trending topics related to coumarin and its derivatives in the broad field of drug discovery.
Highlights
Coumarins are molecules that belong to a very special family
A diversity of journals from different fields publishes research articles and reviews related to the biological interest of both plant extracts containing coumarins and/or synthetic molecules based on this scaffold
We have found very few publications related to these activities, in some cases the antioxidant activity of coumarin derivatives of both natural [28] and synthetic caseThis described the introduction of a piperidine throughfor a linker in posi[29] origin has The beensecond reported
Summary
Coumarins are molecules that belong to a very special family. Their conjugated double ring system makes them interesting molecules for different fields of research. Molecules26020501 especially in the pharmaceutical industry in the synthesis of a large number of synthetic pharmaceutical products [1]. This last application is the main focus of our overview. Received: 10 December 2020 concentration in the tonka bean (Dipteryx odorata) It can be found in sweet woodruff. Published: 19 January 2021 odorata), among others This explains the great interest in the extraction and characterization techniques of natural coumarins, and in the synthesis of their derivatives.
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