Abstract
ObjectiveTo see the changes of cardio-metabolic risk factors overtime in polycystic ovary syndrome vs. control women.MethodsThis study was conducted on 637 participants (85 PCOS and 552 control reproductive aged, 18–45 years) of Tehran Lipid and Glucose Study (TLGS), an ongoing population-based cohort study with 12 years of follow-up. The cardiovascular risk factors of these groups were assessed in three-year intervals using standard questionnaires, history taking, anthropometric measures, and metabolic/endocrine evaluation. Generalized estimating equation was used to analyze the data.ResultsOverall mean of insulin (3.55, CI: 0.66–6.45), HOMA-IR (0.63, CI: 0.08–1.18), and HOMA-β (45.90, CI: 0.86–90.93) were significantly higher in PCOS than in healthy women after adjustment for age, BMI, and baseline levels. However, the negative interaction (follow-up years × PCOS status) of PCOS and normal women converged overtime. Comparing third follow-up with first, insulin and HOMA-IR decreased 10.6% and 5%, respectively in PCOS women; and increased 6.7% and 14.6%, respectively in controls (P<0.05). The results did not show any significant result for other cardio-metabolic variables including WC, lipid profile, FPG, 2-h PG, SBP, and DBP.ConclusionWhile the insulin level and insulin resistance rate were higher in reproductive aged PCOS than in healthy women, the difference of these risk factors decreased overtime. Thus, the metabolic consequences of PCOS women in later life may be lower than those initially anticipated.
Highlights
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age, with a reported prevalence of 4–15% depending on the diagnostic criteria [1]
The results did not show any significant result for other cardio-metabolic variables including Waist circumference (WC), lipid profile, Fasting plasma glucose (FPG), 2-h PG, SBP, and diastolic blood pressure (DBP)
While the insulin level and insulin resistance rate were higher in reproductive aged PCOS than in healthy women, the difference of these risk factors decreased overtime
Summary
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age, with a reported prevalence of 4–15% depending on the diagnostic criteria [1]. The affected women might encounter increased risk of cardio-vascular diseases (CVD), [2,3]. Increased cardio-metabolic risk factors—which are independent of, but exacerbated by obesity—are seen in PCOS women more than in normal controls [4,5]. The literature regarding CVD outcomes, e.g. coronary heart disease, stroke, etc., are inconsistent and there are still uncertainties over differences in CVD related mortalities among PCOS and healthy women [6,7,8,9]. Having said that CVD outcomes were not so deteriorating, as we could expect from higher cardio-metabolic risk factors in PCOS patients in the literature, we should seek the trends of these risk factors in PCOS and normal women
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