Trend Analysis of Superoxide Dismutase 3 (SOD3) and Reactive Oxygen Species (ROS) levels on BioSmart and Safe Bus Passengers

A R Hairul Asri,Udadi Sadhana,Arlita Leniseptaria Antari,Awal Prasetyo,Hehera Rahajeng

doi:10.17485/ijst/v14i34.769

Abstract

Objective: To assess the effect of the Biosmart and safe concept on the levels of superoxide Dismutase 3 (SOD3) and reactive oxygen species (ROS) in the bus passenger nasal wash. Methods: This study is a non-blinding experimental design with a pretest-posttest measurement. The number of participants was 31 passengers of Biosmart and Safe Bus; divided into 2 groups: herbal masks and regular medical masks. Participants were divided into front, middle, and rear seat positions. Findings: The trend of SOD3 and ROS levels in the herbal mask group was increasing, while the trend in the medical mask group was decreasing. There was a significant difference in SOD3 levels in the middle seat position (p = 0.037) and ROS levels in the rear seat position (p = 0.022). There was a strong negative relationship between SOD3 levels and ROS levels in the herbal mask group (p = 0.016, r = -0.611). There was a significant difference in the levels of ROS on pretest-posttest of the medical mask group (p = 0.039), and the ROS levels in the herbal mask group approached a significant value (p = 0.059). There was no significant difference in SOD3 and ROS levels between the herbal mask and medical mask groups (p = 0.937; 0.810). Novelty : The ROS levels of Biosmart and Safe Bus passengers who use Herbal Masks are different from those using regular medical masks with lower levels. The SOD3 levels of Biosmart and Safe bus passengers who use herbal masks are different from those who use higher levels of regular medical masks. Keywords: Biosmart and Safe Bus; herbal mask; nasal wash; ROS; SOD3

Highlights

Respiratory tract infectious diseases are at risk of being transmitted through public transportation such as buses, planes, and trains
This study aims to analyze the cellular response with the balance between oxidant (ROS) and antioxidants (SOD3) as a marker of oxidative stress in public transportation passengers on buses using the Biosmart and Safe bus concepts
Based on (Table 2), there was no significant difference between the increase of superoxide Dismutase 3 (SOD3) levels after treatment in the herbal mask group p = 0.865 (p

Summary

Introduction

Respiratory tract infectious diseases are at risk of being transmitted through public transportation such as buses, planes, and trains This risk increases the frequency of passengers using public transportation /buses.[1] The use of the ventilation system affects infectious airborne particles in the confined spaces such as the cabin of vehicles, ex: cars and buses. When infectious airborne particles and pollutants are inhaled, these particles can penetrate the respiratory epithelial cells present in the nose This condition disrupts cell function by forming reactive oxygen species (ROS) which disrupts the balance of oxidants and antioxidants and results in oxidative stress. This condition is exacerbated if the infectious airborne particles that penetrated can inhibit the activity of antioxidant enzymes such as SOD3 by decreasing the number of transcription factors such as Nrf-2 (Nuclear transcription factor NFE2-related factor2).(4)

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