Abstract
Five new tremulane sesquiterpenes (1–5), together with seven known ones (6–12), were isolated from cultures of the fungus Phellinus igniarius. The new compounds were established as 6β,11,12-trihydroxy-tremul-1(10)-ene (1), 11,12-dihydroxyl-7β-peroxy-hydroxyl-tremul-1(10)-ene (2), 6β,12-dihydroxy-tremulene (3), 10β,12-dihydroxy-tremulene (4), and 12,15-dihydroxy-tremulene (5) on the basis of their MS and NMR data. Compounds 1–6 were evaluated for their vascular-relaxing activities. In preliminary in vitro assays, at 3×10−4M, they showed vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxing rates of 29.9%, 39.9%, 48.5%, 78.7%, 32.3%, and 59.3%, respectively. In addition, compounds 1, 4, and 6 exhibited different levels of vascular-relaxing activities against KCl-induced vasoconstriction with relaxing rates of 31.3%, 57.7%, and 14.0%, as compared with the blank control.
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