Abstract
BACKGROUND: Hydrogen peroxide (H2O2) a key reactive oxygen species, which is made through redox procedure, can induce oxidative damage to several biological macromolecules and play critical role in neurodegenerative diseases. Aim: The current study examined the neuroprotective effect of Trehalose on hair cells death induced by H2O2. Material and method: Hair cells were co-treated by Trehalose and H2O2. The effects of Trehalose on BAX/BCL2 expression ratio and cell viability were assessed by Real time PCR and MTT assay, respectively. Result: The results of Real time PCR and MTT assay indicated that H2O2 induce cell death, and Trehalose have neuroprotective effect and decreases cell death. Conclusion: Our data showed that Trehalose has the protective effect on hair cells death induced by H202
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