Abstract
Treg: tolerance vs immunity.
Highlights
Regulatory T cells (Treg) are requisite for the prevention of autoimmunity, transplant rejection, and tolerance to therapeutic protein delivery
Consistent with its central role in cell proliferation, several upstream and downstream effectors of mTOR are dysregulated in chronically proliferating malignant cells
FltL signaling occurs through the PI3K-mTOR pathway, which is inhibited by rapamycin, raising the question of how these drugs can be combined for therapy
Summary
Regulatory T cells (Treg) are requisite for the prevention of autoimmunity, transplant rejection, and tolerance to therapeutic protein delivery. The immune suppressive effects of rapamycin might accentuate rather than halt tumor growth. Flt3L is being developed to increase T cell activation indirectly via expansion of DC (and to expand NK cells).
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