Abstract
The homeostasis of complex multicellular organisms requires coordinated actions of many types of differentiated cells providing distinct functions. Instability of cell fate can lead to pathological consequences due to loss of original function of the cell and/or gain of undesired function associated with newly acquired cell identity. What signals destabilize cell fate and how cell identity is preserved under homeostatic conditions is poorly understood. On the other hand, differentiated cells may display natural plasticity of cell fate in response to environmental changes. Plasticity of cell identity can also be artificially induced and harnessed for medical purposes as in cellular reprogramming. Thus, a better understanding is needed on the mechanisms controlling stability and plasticity of cell identity.
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