Abstract
E17 and 18 GI tissues were subjected to incisional wounds in vitro. TFF1 induction was seen only in stomach, after as short as 30 min incubation. TFF2 was only induced at E18 in the stomach. TFF3 was induced within 5 min in the rectum. No change in overall expression patterns were seen after wounding. TFF expression is developmentally controlled in the GI tract, and appears before mucous cell differentiation in several tissues. Gene regulation is predicted to be under different control(s) in utero compared with post-natal life. The response to incisional wounding of fetal GI tissue shows differences to the adult.
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