TREC/KREC indicators in newborns at gestation 28–34 weeks

Abstract

RelevancePrimary immunodeficiency states are a heterogeneous group of congenital defects of cells of the immune system, which are clinically manifested in the form of recurrent infectious and autoimmune diseases of varying severity, as well as malignant neoplasms.To determine percentile TREC/KREC indices in premature newborns with various infectious perinatal pathology. Materials and methodsIn order to determine the quantitative content of TREC/KREC copies in peripheral blood, 39 premature infants with various infectious perinatal pathology were examined, which was characterized by the presence of signs of an inflammatory process at the time of determining TREC/KREC, who were in the pediatric department for premature newborns at the RNPC “Mother and Child”. Results and conclusionThe examined infants were born at the gestation period of 28–34 (IU = 32.5 (28.0–33.7)) weeks.The examined infants were born at the gestation period of 28–34 (IU = 32.5 (28.0–33.7)) weeks. Percentile values of quantitative TREC indicators (number of copies × 106 leukocytes) were: 3 percentile – 1,511.00, 10 percentile – 3,715.00, 25 percentile – 7,426.00, 50 percentile – 11,355.00, 75 percentile – 26,101.50, 90 percentile – 35,047.50, 97 the percentile is 44,582.50.Percentile values of quantitative KREC indicators (number of copies × 106 leukocytes) were: 3 percentile - 1,526.50,10 percentile - 2,620.00, 25 percentile - 3,535.00, 50 percentile - 12,251.00, 75 percentile - 24,173.00, 90 percentile - 33,130.00, 97 percentile - 73,231.00.