TREATMENTS OF LIVER METASTASES FROM COLORECTAL CANCERS

Abstract

We reviewed 21 patients with resected hepatic metastases from colorectal cancer and considered the significance of hepatic resection and hepatic artery infusion (HIA) for the colorectal hepatic metastases. The mean survival of the hepatic resection group was 23 months and the cumulative 3-year survival rate was 37.4%. The recurrences after hepatic resection were observed in nineteen cases (90.5%). The sites of the recurrences were liver, lung, and local recurrence in that order of frequency. The extent of liver metastases was divided into three groups (H1, H2, H3). Each group was analyzed with regard to three kinds of treatment: 21 cases with hepatic resection, 23 cases with arterial infusion via the hepatic artery (HAI(+)), and 51 cases without hepatic resection or arterial infusion (HAI(-)). The survival rate for the each therapy was compared in the H1, H2 and H3 groups. In the H1 group, the cumulative 3-year survival rate was 43.7% (hepatic resection), 0% (HAI(+)), 6.5% (HAI(-)). In the H2 group the cumulative 2-year survival rate was 0% (hepatic resection), 25.7% (HAI(+)), and 35.0% (HAI(-)). In the H3 group the 2-year survival rate was 0% (HAI(+)) and 14.2% (HAI(-)). There were no statistically significant differences among the therapeuetic methods in each group. But we considered that hepatic resection in H1 was somewhat effective.