Abstract
Cancer Ovarian cancer is frequently fatal because it is difficult to detect and challenging to treat. Using cell lines and patient tumors, Kurimchak et al. analyzed the functional kinome of high-grade serous ovarian carcinoma (HGSOC) and identified a kinase called MRCKA as being important for HGSOC cell survival and tumor growth. Decreasing abundance of this kinase or inhibiting its activity killed HGSOC cells but led to activation of other survival-promoting kinases in the remaining cells, which could be targeted by cotreating cells with a different kinase inhibitor or platinum-based chemotherapy. Sci. Signal. 13 , eaax8238 (2020).
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