Treatments for mitochondrial dysfunction associated with autism spectrum disorders

Abstract

Mitochondrial disease (MD) and dysfunction are associated with autism spectrum disorder (ASD) and most likely affect a substantial number of children with ASD. The mitochondrion is the powerhouse of the body's cells which supports and is supported by many metabolic systems, so mitochondrial dysfunction can have widespread consequences on cellular metabolism, especially in high energy cells like the brain, gastrointestinal tract and immune system, and especially during critical periods of high energy demand like childhood. This article reviews the treatments for MD as applied to children with ASD. We discuss supportive measures which aim at preventing further damage from occurring due to malfunctioning mitochondria, treatment with high dose vitamins that can support metabolism in light of dysfunctional mitochondria, dietary changes that can be useful in mitochondrial disease, and secondary organ systems to investigate due to mitochondrial dysfunction. We also discuss several treatments that have been reported to be of benefit in children with ASD which are also treatments that are standard of care for MD. This review provides a guide for appropriate treatments for children with ASD/MD and children with ASD that have mitochondrial dysfunction.