Abstract

Specific behavioral (e.g., cognitive-behavioral therapy [CBT]) and pharmacological (e.g., naltrexone, nalmefene, lithium) treatments significantly reduce the symptoms of pathological gambling (now termed gambling disorder in DSM-5) in the short term compared with waitlist or placebo. The long-term benefits of pharmacological treatment for gambling disorder have not been adequately tested. Although several studies suggest that CBT is effective for trichotillomania, only two pharmacological treatment studies in adults (N-acetylcysteine, olanzapine) for this disorder have shown promise. Studies of group CBT have demonstrated benefit for compulsive buying. However, controlled pharmacological studies have shown mixed results.

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