Treatment with Recombinant Factor XIII (Tretten) in a Pregnant Woman with Factor XIII Deficiency

Abstract

Patient: Female, 37Final Diagnosis: Factor XIII deficiencySymptoms: Bleeding • miscarriageMedication: —Clinical Procedure: —Specialty: HematologyObjective:Rare diseaseBackground:Factor XIII deficiency is associated with recurrent miscarriages in women.Case Report:In this report, we present a patient with factor XIII deficiency and some comorbidities who had had previous miscarriages. She began treatment with factor XIII subunit A (XIII-A) replacement treatment Recombinant factor XIII (Tretten) at a dose of 2500 units monthly and was able, for the first time, to carry a pregnancy almost to term. Although she experienced some obstetrical complications, she delivered a healthy baby. To the best of our knowledge, this is the first report of the use of Tretten during pregnancy.Conclusions:Tretten, which is not indicated in pregnancy, offered a safe, effective treatment for miscarriages secondary to factor XIII-A deficiency in our patient. Further research is required to confirm this finding.