Abstract
Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to airway remodeling and the deterioration of lung function. Viticis Fructus (VF) has long been used in China and Korea as a traditional herbal remedy for treating various inflammatory diseases. Previously, we have isolated a novel phytochemical, pyranopyran-1, 8-dione (PPY), from VF. This study was conducted to evaluate the ability of PPY to prevent airway inflammation and to attenuate airway responses in a cockroach allergen-induced asthma model in mice. The mice sensitized to and challenged with cockroach allergen were treated with oral administration of PPY. The infiltration of total cells, eosinophils and lymphocytes into the BAL fluid was significantly inhibited in cockroach allergen-induced asthma mice treated with PPY (1, 2, or 10 mg/kg). Th2 cytokines and chemokine, such as IL-4, IL-5, IL-13 and eotaxin in BAL fluid were also reduced to normal levels following treatment with PPY. In addition, the levels of IgE were also markedly suppressed after PPY treatment. Histopathological examination demonstrated that PPY substantially inhibited eosinophil infiltration into the airway, goblet cell hyperplasia and smooth muscle hypertrophy. Taken together, these results demonstrate that PPY possesses a potent efficacy on controlling allergic asthma response such as airway inflammation and remodeling.
Highlights
Asthma is a chronic inflammatory disease of the lungs that is characterized by airway inflammation, airway hyper-responsiveness (AHR) and airflow obstruction [1,2]
Eosinophils can affect the structural changes that occur in the airways of asthma patients, including goblet cell hyperplasia, enlarged submucosal mucus glands, and airway smooth muscle hypertrophy
Since the main target for PPY was believed to be lung epithelial cells [22], it is more reasonably to compare the action of PPY with Montelukast than corticosteroid in this study
Summary
Asthma is a chronic inflammatory disease of the lungs that is characterized by airway inflammation, airway hyper-responsiveness (AHR) and airflow obstruction [1,2]. Airway inflammatory disease causes recurrent episodes of wheezing, breathlessness, chest tightness and coughing, especially at night and early in the morning. These episodes are usually associated with a variable amount of airflow obstruction that is often reversible. Allergic airway inflammation causes an associated increase in the existing bronchial hyper-responsiveness to a variety of stimuli. IL-4 plays an important role in eosinophil infiltration into lung tissues, B cell maturation, and IgE synthesis. Eosinophils can affect the structural changes that occur in the airways of asthma patients, including goblet cell hyperplasia, enlarged submucosal mucus glands, and airway smooth muscle hypertrophy
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
