Treatment with Light-Emitting Diodes of Wavelength 863 nm Delays DMBA/TPA-Induced Skin Tumor Formation and Decreases Proinflammatory Cytokine Levels in ICR Mice.

Ji On Park,Sangjoon Mo,Hyeyoon Goo,Yeon Hee Cho,Namgue Hong,Byeong-Il Lee,Emiliano Antiga,Hyeong Ju Park,Sun-Hyang Choi,Min Young Lee,Jin-Chul Ahn,Eun Young Kim

doi:10.1155/2022/4400276

Ji On Park, Sangjoon Mo + Show 10 more

Open Access

https://doi.org/10.1155/2022/4400276

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Abstract

The popularity of light/energy devices for cosmetic purposes (e.g., skin care) is increasing. However, the effects and underlying mechanisms remain poorly understood. Commencing in the 1960s, various studies have evaluated the beneficial effects of a light source on cells and tissues. The techniques evaluated include low-level light (laser) therapy and photobiomodulation (PBM). Most studies on PBM used red light sources, but, recently, many studies have employed near-infrared light sources including those of wavelength 800 nm. Here, we used a light-emitting diode (LED) array with a wavelength of 863 nm to treat DMBA/TPA-induced mouse skin tumors; treatment with the array delayed tumor development and reduced the levels of systemic inflammatory cytokines. These results suggest that light therapy could be beneficial. However, the effects were small. Further studies on different skin tumors using an optimized LED setup are required. Combination therapies (conventional methods and an LED array) may be useful.

Highlights

In recent years, the interest in skin care has increased, given the desire for an ideal appearance, increase in disposable income, and people being more health-conscious
Negative effects of lasers were reported in the late 1960s; since many studies have explored the positive effects of light sources on cells and tissues [2,3,4]
DMBA was used to initiate skin tumors, and TPA was employed to promote tumor growth; both were purchased from Sigma-Aldrich (USA), dissolved in acetone from Daejung Chemicals & Metals (Korea), and stored at 0°C

Summary

Introduction

The interest in skin care has increased, given the desire for an ideal appearance, increase in disposable income, and people being more health-conscious. The skin is susceptible to light-induced, age-related deterioration [1]. Dermatologists employ laser or light energy treatments. The popularity of light energy devices for cosmetic purposes (e.g., skin care) is increasing. Negative effects of lasers were reported in the late 1960s; since many studies have explored the positive effects of light sources on cells and tissues [2,3,4]. The techniques evaluated include low-level light (laser) therapy and photobiomodulation (PBM) employing light-emitting diodes (LEDs) [5]. Light photons are absorbed by photoreceptors such as chromophores and cytochrome C oxidase, promoting metabolism [3]

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