Treatment with Herbal Mouthwash Mediates Improvement of Symptoms in Xerostomia and Oral Mucositis patients

Jose Figueroa,Jonathan Berrout,Gianluca Rotino,Diane Nguyen,Scott Dahlbeck

doi:10.18314/jnb.v4i2.1060

Jose Figueroa, Jonathan Berrout + Show 3 more

Open Access

https://doi.org/10.18314/jnb.v4i2.1060

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Abstract

Oral discomfort and pain are frequent side-effects of many popular prescription medications. Over 500 prescription drugs are known to result in the development of adverse oral conditions. In fact, approximately 40% of patients suffer from xerostomia and oral mucositis, as a result of cancer medications. The number of affected individuals is expected to continue to rise, given that the incidence of major cancers is predicted to grow over the next decade. Regrettably, there are currently lacks of treatments available to effectively improve xerostomia and oral mucositis symptoms. Interestingly, the use of several herbal ingredients (such as chamomile, cinnamon, and peppermint oil) has been reported to effectively improve pain and oral dryness. For this reason, we examined the effectiveness of an herbal mouthwash, Nature’s Herbal (a blend of cinnamon oil, chamomile, cranberry, and peppermint extract), to alleviate symptoms of oral pain and dry mouth exhibited by patients diagnosed with oral mucositis and xerostomia. Daily treatment with the mouthwash induced a 53% ± 6% and 33.2% ± 3.8% improvement in the severity of symptom, for the oral mucositis and xerostomia patients groups, respectively. Overall, the herbal mouthwash induced an improvement in 91% of oral mucositis and 83% of xerostomia patients.

Highlights

Introduction therapy, and checkpoint inhibitors have been observed to cause debilitating oral discomfort for patients [2]
Among patients diagnosed with xerostomia, the use of the herbal mouthwash led to an improvement in 83.3% (10 of 12 participants) of patients (Figure 1b), with an average improvement in the severity of symptoms of 33.2% ± 3.8% (Table 1)
We evaluated the effectiveness and safety of an herbal-based mouthwash, Nature’s Herbal, to improve symptoms of pain and dry mouth, exhibited by patients diagnosed with oral mucositis and xerostomia

Summary

Introduction

Introduction therapy, and checkpoint inhibitors have been observed to cause debilitating oral discomfort for patients [2]. Often overlooked is the fact that the use of medication frequently results in the development of adverse effects for patients. This possesses a significant issue since patients are often unable to discontinue the use of the prescription drugs causing oral discomfort. Among patients diagnosed with xerostomia, the use of the herbal mouthwash led to an improvement (defined as ≥ 25% improvement of dry mouth symptoms) in 83.3% (10 of 12 participants) of patients (Figure 1b), with an average improvement in the severity of symptoms of 33.2% ± 3.8% (Table 1). We evaluated the effectiveness and safety of an herbal-based mouthwash, Nature’s Herbal, to improve symptoms of pain and dry mouth, exhibited by patients diagnosed with oral mucositis and xerostomia. The results of our study indicated that this herbal formula is safe for daily use and capable of improving the symptoms of oral mucositis and xerostomia

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