Abstract
In previous investigations, we demonstrated that pre-exposure of different cell cultures to radiofrequency fields can reduce the damage induced by genotoxic agents, an effect resembling the so-called adaptive response. In this study, we pre-exposed human peripheral blood lymphocytes and Chinese hamster lung fibroblast cell line to 1950 MHz, UMTS (Universal Mobile Telecommunication System) signal, for 20 h, and then treated cultures with Mitomycin-C. After confirming the induction of an adaptive response in terms of the reduction of micronuclei formation, we observed that such a response was negated by treatments with 3-aminobenzamide. Since 3-aminobenzamide is an inhibitor of poly (ADP-ribose) polymerase enzyme, which is involved in DNA repair, these results support the possible involvement of DNA repair mechanisms in radiofrequency-induced adaptive response.
Highlights
The adaptive response (AR) is a universal response of cells to very small doses of ionizing radiation or chemicals, which is manifested by an increased resistance to the damaging effects of higher doses of the same, or other, physical or chemical agents
The phenomenon has been characterized with respect to the exposure conditions: 900 MHz and 1950 MHz, different signal modulations, and bandwidth at specific absorption rates (SAR) ranging from 0.15 to 1.25 W/kg, with effective conditions depending on the cell type investigated [4,5,6,7,8,9,10]
Public Health 2019, 16, 2768 we recently demonstrated that pre-exposure to 1950 MHz, Universal Mobile Telecommunication System (UMTS) signal, reduced menadione-dependent DNA oxidative damage in human neuroblastoma cell cultures by enhancing antioxidant scavenging efficiency and restoring DNA repair capability [9]
Summary
The adaptive response (AR) is a universal response of cells to very small doses of ionizing radiation or chemicals, which is manifested by an increased resistance to the damaging effects of higher doses of the same, or other, physical or chemical agents. Over the last ten years, our research group has repeatedly observed, in in vitro experiments, a protective effect induced by radiofrequency (RF) pre-exposure, referred to as RF-induced AR Such protection has been detected in several cell types, against several chemical and physical agents, and by analyzing several cellular endpoints. Independent research groups have reported similar observations in in vitro and in vivo experiments, under different exposure conditions, in different biological models, and by addressing several biological endpoints. These studies were reviewed and gaps in knowledge were identified [11]
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