Abstract
Status epilepticus basis for sustained duration and response to treatment can be divided into early status epilepticus, established status epilepticus, refractory status epilepticus and super-refractory status epilepticus.This article reviews the treatment approaches.Mainly conducted a systematic review for treatment strategy of refractory status epilepticus and super-refractory status epilepticus.Including pathogenic factors and cerebral damage analysis.It proposed super-refractory status epilepticus is an uncommon but important clinical problem with high mortality and morbidity rates.The published world literature on the following treatments is critically evaluated: anaesthetic agents, anti-epileptic drugs, magnesium infusion, pyridoxine, steroids and immunotherapy, ketogenic diet, hypothermia, emergency resective neurosurgery and multiple subpial transection, transcranial magnetic stimulation, vagal nerve stimulation, deep brain stimulation, electroconvulsive therapy, drainage of the cerebrospinal fluid and other older drug therapies.The importance of treating the identifying cause is stressed.And recommend protocols take a staged approach to treatment.A protocols and flowcharts for managing refractory status epilepticus and super-refractory status epilepticus are suggested. Key words: Epilepticus; Refractory/super-refractory; Treatment strategy
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