Treatment strategies in recurrent esophageal or junctional cancer after neoadjuvant therapy followed by esophagectomy.

Abstract

e15024 Background: Recurrent disease (RD) after potentially curative treatment for esophageal or junctional cancer is common and survival after recurrence is poor. Potentially curative strategies are possible in limited occasions and palliative systemic therapy or supportive care are often the only therapies possible. Little is known about survival after recurrence and factors influencing treatment success. We aimed to assess the recurrence patterns and overall survival (OS) of patients who developed RD after curative treatment. Methods: Patients with RD of esophageal or junctional cancer between 1994 and 2014 after potentially curative esophagectomy preceded by neoadjuvant chemo(radio)therapy were included in this retrospective cohort study. A logistic regression analysis was performed to assess predictive factors for receiving treatment aimed at radical tumor eradication. Results: Recurrence was diagnosed in 219 of 503 patients (43.5%). 212 of 219 patients (96.8%) were evaluable for dissemination patter...