Treatment results of tuberculous patients in Assiut Chest Hospital

Abstract

Aims The improvement of the quality of TB treatment is essential to control of TB. The aims of this study were to identify the outcomes of TB treatment in patient recorded in Assiut Chest Hospital during the period from 2011 to 2015 and factors associated with undesirable treatment outcome and to estimate proportion of drug resistance among TB patients and identify factors associated with it. Patients and methods This study was a descriptive retrospective review of TB patients' registry. All tuberculous patients notified to the TB registry in Assiut Chest Hospital in the period from 1 January 2011 to 31 December 2015 and completed at least 6 months of treatment management were included in the study. Patients' records were reviewed for the following data: personal data, presenting symptoms, pattern of TB, regimen of treatment, and drug-resistant TB. Results The percentage patients with drug resistance were 60.9%. A total 75.1% of patients were cured and 5.1% of patients died. Cure rate was significantly higher in patients with extrapulmonary TB compared with 63.5% in pulmonary TB patients. The predictors for undesirable treatment outcomes were male sex, positive family history, pulmonary TB patients. Conclusion The success rate of all registered patients was satisfactory but, below WHO target, one-fifth showed failure of treatment was associated with male sex, illiterate, and drug-resistance Mycobacterium tuberculosis, success treatment was highest in extrapulmonary TB patients, cure rate was highest in nonresistant TB patients, drug resistance represented about two-thirds of all studied TB patients, and ~ 65% of pulmonary TB patients had drug resistance.