Abstract
Holmes tremor is a rare symptomatic movement disorder, characterized by a combination of resting, postural, and action tremors. It is usually caused by lesions involving the brainstem, thalamus, and cerebellum. It is often difficult to treat, many medications have been used with varying degrees of success. It may respond to stereotactic thalamotomy and deep brain stimulation in ventralis intermedius nucleus. Here I report a case of Holmes tremor secondary to multiple sclerosis that treated with L-dopa/carpidopa and showed marked improvement. A relevant literature search was performed, using PubMed for Holmes tremor as labelled in the literature. I included all patients diagnosed with Holmes tremor who responded to medical treatment. I found 27 cases, which are summarized in this review. This report describes a patient with Holmes tremor, who responded very well to Levodopa. This outcome suggests that Levodopa should be considered in the initial management of Holmes tremor.
Highlights
Holmes tremor is a rare symptomatic movement disorder, characterized by a combination of resting, postural, and action tremors
In 1904, Gordon Holmes first described a syndrome characterized by a low-frequency resting tremor accentuated by posture and intentional movement
A delay of between 4 weeks to 2 years is commonly observed between lesion onset and the occurrence of tremor, suggesting a rearrangement of central pathways in the brain or an aberrant result of plasticity. [1, 3, 4] Most of lesions that cause this kind of tremor often located in the upper brainstem, thalamus, and cerebellum
Summary
Holmes tremor is a rare symptomatic movement disorder, characterized by a combination of resting, postural, and action tremors. Introduction Holmes tremor (HT) is characterized by a combination of resting, postural, and action tremors and is usually caused by lesions involving brainstem, thalamus, and cerebellum. HT is an irregular, slow-frequency (
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