Abstract

The radionuclide 117mSn (tin-117m) embedded in a homogeneous colloid is a novel radiosynoviorthesis (RSO) device for intra-articular (IA) administration to treat synovial inflammation and mitigate osteoarthritis (OA) in dogs. A study to evaluate tin-117m colloid treatment response in dogs with OA was conducted at two centers, the School of Veterinary Medicine at Louisiana State University, and at a referral practice in Houston, Texas. The tin-117m colloid was administered per-protocol to 14 client-owned dogs with radiographically confirmed, grade 3 OA in one or both elbow joints. Dog owners and attending clinicians assessed the level of pain at baseline (BL) and the post-treatment pain response at 90-day intervals for one year. Owners assessed treatment response according to a pain severity score (PSS) and a pain interference score (PIS) as defined by the Canine Brief Pain Inventory. Clinicians reported a lameness score using a 0-5 scale, from no lameness to continuous non-weight bearing lameness, when observing dogs at a walk and a trot. The rate of treatment success as determined by improved mean PSS and PIS scores reported by dog owners was >70% at all time points. Clinicians reported an improved mean pain score from BL at post-treatment Days 90 (p<0.05), 180, and 270. The dog owner and clinician assessments of treatment success were significantly correlated (p>0.05) at Day 90 and Day 180 time points. Results indicated that a single IA dose of tin-117m colloid provided a significant reduction in pain and lameness and improved functionality for up to a full year, with no adverse treatment related effects, in a high percentage of dogs with advanced, clinical OA of the elbow joint.

Highlights

  • It has been reported that as many as 20% of dogs over 1 year of age are afflicted with osteoarthritis (OA) [1]

  • When it occurs in the canine elbow, OA most often develops as a sequela to elbow dysplasia [2], a common occurrence in medium and large sized dogs [3, 4]

  • The mean pain severity score (PSS) score of 3.46 at Day 90 and 2.33 at Day 270 were statistically significant improvements (p

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Summary

Introduction

It has been reported that as many as 20% of dogs over 1 year of age are afflicted with osteoarthritis (OA) [1]. When it occurs in the canine elbow, OA most often develops as a sequela to elbow dysplasia [2], a common occurrence in medium and large sized dogs [3, 4]. Treatment of dogs with grade 3 elbow osteoarthritis using radiosynoviorthesis a publicly available link to the study report along with a listing of the appendices with relevant dataset titles: https://www.synovetin.com/ resources/news

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