Abstract
The radionuclide 117mSn (tin-117m) embedded in a homogeneous colloid is a novel radiosynoviorthesis (RSO) device for intra-articular (IA) administration to treat synovial inflammation and mitigate osteoarthritis (OA) in dogs. A study to evaluate tin-117m colloid treatment response in dogs with OA was conducted at two centers, the School of Veterinary Medicine at Louisiana State University, and at a referral practice in Houston, Texas. The tin-117m colloid was administered per-protocol to 14 client-owned dogs with radiographically confirmed, grade 3 OA in one or both elbow joints. Dog owners and attending clinicians assessed the level of pain at baseline (BL) and the post-treatment pain response at 90-day intervals for one year. Owners assessed treatment response according to a pain severity score (PSS) and a pain interference score (PIS) as defined by the Canine Brief Pain Inventory. Clinicians reported a lameness score using a 0-5 scale, from no lameness to continuous non-weight bearing lameness, when observing dogs at a walk and a trot. The rate of treatment success as determined by improved mean PSS and PIS scores reported by dog owners was >70% at all time points. Clinicians reported an improved mean pain score from BL at post-treatment Days 90 (p<0.05), 180, and 270. The dog owner and clinician assessments of treatment success were significantly correlated (p>0.05) at Day 90 and Day 180 time points. Results indicated that a single IA dose of tin-117m colloid provided a significant reduction in pain and lameness and improved functionality for up to a full year, with no adverse treatment related effects, in a high percentage of dogs with advanced, clinical OA of the elbow joint.
Highlights
It has been reported that as many as 20% of dogs over 1 year of age are afflicted with osteoarthritis (OA) [1]
When it occurs in the canine elbow, OA most often develops as a sequela to elbow dysplasia [2], a common occurrence in medium and large sized dogs [3, 4]
The mean pain severity score (PSS) score of 3.46 at Day 90 and 2.33 at Day 270 were statistically significant improvements (p
Summary
It has been reported that as many as 20% of dogs over 1 year of age are afflicted with osteoarthritis (OA) [1]. When it occurs in the canine elbow, OA most often develops as a sequela to elbow dysplasia [2], a common occurrence in medium and large sized dogs [3, 4]. Treatment of dogs with grade 3 elbow osteoarthritis using radiosynoviorthesis a publicly available link to the study report along with a listing of the appendices with relevant dataset titles: https://www.synovetin.com/ resources/news
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