Treatment outcomes of non tuberculous mycobacterial (NTM) pulmonary disease. Multicenter study

Abstract

Aims: to evaluate the outcomes of NTM pulmonary disease treatment in real life practice Methods: retrospective study. All respiratory NTM isolations from 5 hospitals in northern Spain between 2012 and 2017 were analyzed. Microbiology, demographic data, radiologic features, treatment and outcome variables (cure, death, therapeutic failure) were collected Results: 395 patients has at least one NTM isolation, 147 met 2007 ATS disease criteria and / or received treatment for NTM pulmonary disease. 34 patients did not receive treatment despite meeting ATS criteria. Main results are shown in the attached tables. Multivariate analysis showed that only age> 75, the diagnosis of neoplasia and COPD were significant associated to all-cause mortality. Conclusions: Mortality in patients with NTM pulmonary disease is high but mainly related to the underlying comorbidities of the patients. Therapeutic failure is associated with the presence of M abcessus and bronchiectasis-nodular pattern in the CT scan.