Abstract
BackgroundMonitoring the treatment outcomes of tuberculosis and determining the specific factors associated with unsuccessful treatment outcome are essential to evaluate the effectiveness of tuberculosis control program. This study aimed to assess treatment outcomes and explore the factors associated with unsuccessful outcomes among new pulmonary smear positive and negative tuberculosis patients in Anqing, China.MethodsA nine-year retrospective study was conducted using data from Anqing Center for Diseases Prevention and Control. New pulmonary tuberculosis patients treated with two six-month regimens were investigated. Non-conditional logistic regression was performed to calculate odds ratios and 95% confidence intervals for factors associated with unsuccessful outcomes.ResultsAmong 22,998 registered patients (16,939 males, 6059 females), 64.54% were smear-positive patients. The treatment success rates was 95.02% for smear-positive patients and 95.00% for smear-negative patients. Characteristics associated with an higher risk of unsuccessful treatment among smear-positive patients included aged above 35 years, treatment management model of self-medication, full-course management and supervision in intensive phase, unchecked chest X-ray, cavity in chest X-ray, and miliary shadow in chest X-ray, while normal X-ray was negative factor. Unsuccessful treatment among smear-negative patients was significantly associated with age over 45 years, treatment management model of full-course management, unchecked chest X-ray, presence of miliary shadow in chest X-ray and delay over 51 days.ConclusionsTuberculosis treatment in Anqing area was successful and independent of treatment regimens. Special efforts are required for patients with unsuccessful outcomes.
Highlights
Monitoring the treatment outcomes of tuberculosis and determining the specific factors associated with unsuccessful treatment outcome are essential to evaluate the effectiveness of tuberculosis control program
Previous reports emphasized that in Ethiopia, factors independently associated with increased risk of unsuccessful TB treatment outcome were older age, habitation in rural areas, lack of contact person, sputum smear negative treatment category at initiation of treatment, smear positive sputum test result at second month after initiation treatment, retreatment cases and Human Immunodeficiency Virus (HIV) positive status [4,5,6]
In a study in European area showed that the risk of unsuccessful treatment was significantly higher among male patients of foreign origin and increasing age, who were multidrug-resistant tuberculosis (MDR-TB) cases [7]
Summary
Monitoring the treatment outcomes of tuberculosis and determining the specific factors associated with unsuccessful treatment outcome are essential to evaluate the effectiveness of tuberculosis control program. This study aimed to assess treatment outcomes and explore the factors associated with unsuccessful outcomes among new pulmonary smear positive and negative tuberculosis patients in Anqing, China. Previous reports emphasized that in Ethiopia, factors independently associated with increased risk of unsuccessful TB treatment outcome were older age, habitation in rural areas, lack of contact person, sputum smear negative treatment category at initiation of treatment, smear positive sputum test result at second month after initiation treatment, retreatment cases and HIV positive status [4,5,6]. In a study in European area showed that the risk of unsuccessful treatment was significantly higher among male patients of foreign origin and increasing age, who were multidrug-resistant tuberculosis (MDR-TB) cases [7]. Unemployment [8], longer duration of TB symptoms [9], lower educational level [10] and diabetes [11] were risk factors for unsuccessful treatment outcome
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