Abstract
Neisseria gonorrhoeae (NG) is becoming increasingly less susceptible to the extended spectrum cephalosporin (ESC), which has been recommended for first-line treatment, and cases of treatment failure are being reported globally. An era of untreatable gonorrhea may have started, and it calls for novel treatment strategies. Essential actions should include use of higher doses of ceftriaxone administered as part of dual therapy and further development of alternative drug combinations. This review focuses on the global spread of ESC resistant NG and potential treatment options for the future.
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