Abstract
Introduction: Spontaneous clearance of warts has been reported with the development of cell mediated immunity. Various antigens and vaccines have been used for the non specific stimulation of cell mediated immunity and purified protein derivative (PPD) is one of them.Objective: To assess the effectiveness of intralesional PPD injection for the clearance of cutaneous warts.Methodology: This is an open labeled study and non-probability sampling method was used for enrolling the cases. Patients with cutaneous warts were injected with PPD intralesionally (2.5 TU) at an interval of 2 weeks for a total of five sessions and they were followed for 6 months after they received the last session therapy.Results: A total of 52 patients,29 males and 23 females, were enrolled in the study and among them 28 patients had verruca vulgaris,12 patients had verruca plantaris, 9 patients had periungual wart and 3 patients had verruca plana. Total clearance of warts was seen in 78.8%(41) of patients, however 21.2% (11) patient did not respond to the therapy. Most of the patients tolerated the therapy well and few of them had mild side effects like erythema, pain and oedema at the site of injection.Conclusion: Immunotherapy with intralesional injection of PPD is a safe and effective way to treat cutaneous warts with good response rate. BJHS 2018;3(2)6: 463-467.
Highlights
Infec on of kera nocytes by human papilloma virus (HPVs) causes warts in human beings
Total clearance of warts was seen in 78.8%(41) of pa ents, 21.2% (11) pa ent did not respond to the therapy
This study aims at evalua ng the efficacy and safety of intralesional Purified protein deriva ve, ubiquitously used, standardized, available, safe and inexpensive an gen, in the treatment of cutaneous warts
Summary
Infec on of kera nocytes by human papilloma virus (HPVs) causes warts in human beings. Because these viruses have tropism for epithelial cells they manifest clinically as mucocutaneous lesions.[1] Due to their long period of latency in the host cells they are prone to recurrences causing both benign and malignant lesions. A lot of standard modali es are available at present for the treatment of warts and most of them u lize local destruc on of virally infected ssues. The locally destruc ve methods available at present are chemical or electric cauteriza on, electrofulgura on, carbon dioxide laser or cryotherapy. A variable response has been observed with the use of An gens such as the measles, mumps, and rubella (MMR) vaccine; Candida albicans; Bacillus Calme e–Guérin (BCG), and Mycobacterium indicus pranii injected intralesionally.[4]
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