Abstract
IN THE year 1948 Woodward 1 obtained excellent results in the treatment of 10 patients with endemic typhoid on the Malay Peninsula with chloramphenicol (chloromycetin®). Two patients relapsed, but a second course of therapy was effective. By 1949 this series had been extended to 44 cases, with continued excellent results. 2 Further reports on the treatment of endemic typhoid with chloramphenicol in India have been made by Shah. 3 Vakil 4 and Patel. 5 In the 53 cases reported by them, there were 7 relapses which responded to a second course of therapy and 3 deaths 5 occurring in the first 48 hours of treatment. Shah 3 felt that results were excellent only in those cases in which treatment was started before the tenth day of illness. Knight 6 treated 13 patients in Mexico, with good results. Murgatroyd 7 reported one case from Great Britain in which treatment for only
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