Abstract
Ethanol extract of Bulgarian propolis (Et-Blg) was administered by oral route in doses ranging from 25 to 100 mg/kg body weight in experimental Trypanosoma cruzi-infected Swiss mice. Treatment with 50 mg Et-Blg/kg body weight/day led to a decrease in parasitemia and showed no hepatic or renal toxic effect. Treatment with Et-Blg led to a decrease in the spleen mass and modulated the initial inflammatory reaction as demonstrated by analysis of the leukocyte profile in peripheral blood, quantification of T cells subsets, and phenotypic markers in the spleen. Preferential expansion of CD8 + and partial inhibition in the increase of CD4 +CD69 + and CD8 +CD69 + in CD4 +CD44 + and CD8 +CD44 + and in the decrease of CD8 +CD62L in Trypanosoma cruzi-infected mice were also observed. Taken together, our data indicate that treatment of Trypanosoma cruzi-infected mice with Et-Blg interferes with the basic properties of immune cells.
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