Abstract
1.1. If an endometrial biopsy taken at the onset of menstruation reveals an early secretory pattern, it is good evidence of a corpus luteum deficiency.2.2. Since blood levels of progesterone are not usually determined, this is the only clinical method by which this diagnosis may be established.3.3. The incidence of this syndrome among infertile women is about 25.9 per cent.4.4. Spontaneous return to normal corpus luteum function may occur.5.5. The therapeutic agents which were occasionally successful were thyroid, estrogens, combined estrogen-progesterone, and gonadotrophin. Cortisone was unsuccessful in a small group of women.6.6. The luteal deficiency syndrome may play a prominent part in a sterility problem. After investigation and treatment, one in three of our patients conceived.
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