Abstract
The objective of the work was to formulate the features of the tactics of orthodontic treatment of patients with maxillary canine and first premolar transposition in combination with mesial malocclusion.
 Based on the literature data and our own clinical experience, a treatment algorithm is proposed, considering the transposition teeth location, sagittal and transversal teeth’s roots position/direction, alveolar bone tissue volume, gum biotype, lack of space in anterior area of upper dental arch and degree of facial skull bones size/position disproportion.
 The proposed treatment strategy is illustrated by two clinical cases.
 Conclusions are drawn about the features of the treatment according to the proposed tactics.
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