Abstract
SINCE THE PUBLICATION of Bumke's 1 paper in 1902, paraldehyde has been generally accepted as a useful drug in treatment of delirium tremens. With introduction of phenothiazines, these drugs have gained clinical acceptance, but there are few controlled studies reported in literature. Friedhoff and Zitrin 2 demonstrated that patients receiving paraldehyde recovered more quickly than those treated with chlorpromazine. Hart 3 found no significant difference in recovery time of delirium tremens patients treated with promazine compared to those treated with paraldehyde. In patients without delirium tremens, group treated with promazine showed a shorter duration of anxiety and agitation. Laties and colleagues, 4 in a double-blind study comparing promazine and chlorpromazine in delirium tremens, stated that the drugs were essentially indistinguishable in performance. Gruenwald and associates 5 concluded that patients with mild to moderate symptoms responded promptly to either promazine or triflupromazine, but patients in
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