Treatment of Sodium Balance Disorders: Water Intoxication and Salt Toxicity

Abstract

Electrolyte disorders are commonly identified in food animal medicine. Some of these electrolyte disturbances require that the veterinarian be aware of the potential for causing harm during routine fluid therapy. Hyponatremia (water intoxication) and hypernatremia (salt toxicity) are two such disorders. Both create osmolar disturbances that effect changes in the brain's osmolar state. During fluid resuscitation it is possible to cause iatrogenic central nervous system damage in these cases. It is important to recognize those cases where sodium imbalance may complicate routine therapy, understand the underlying mechanisms for osmolar changes in the plasma and brain, and know the appropriate steps to take for safe correction of the sodium disturbance.