Treatment of rotenone induced neurodegeneration by taurine and hesperidin

Abstract

Taurine (2-aminoethane sulphonic acid) is a sulphonic acid which is derived from cysteine and is widely distributed in animal tissues. It is one of the most abundant amino acid in mammals and plays several crucial roles including modulation of calcium signaling, osmoregulation and membrane stabilization. Hesperidin occurs in the cells in crystalline, feather-like aggregates or sphaerocrytalline masses and it exhibits pharmacological and biological properties such as anti-inflammatory, anticarcinogenic, inhibit bone loss, lowering of lipid, hypoglycaemic and antioxidant activities. The current study was performed to evaluate the effect of taurine and hesperidin on neurodegeneration resulted from rotenone administration by a dose of 1.5 mg/kg b.wt three times per week for two months. Also we summarize recent findings emphasizing the role of catecholamines neurotransmitters, Tyrosine hydroxylase and oxidative stress in neurodegenerative disease model. These rats received taurine and hesperidin through gastric intubation daily for one month after rotenone administration. The results revealed that taurine and hesperidin treatment significantly ameliorated the decreased levels of the catecholamines neurotransmitters and Tyrosine hydroxylase which were decreased as after rotenone injection. Moreover, taurine and hesperidin treatment ameliorated lipid peroxidation and catalase levels.