Abstract
SummaryThe results of prolonged treatment with cortisone in 50 patients with rheumatoid arthritis are reported. The treatment was discontinued on account of unsatisfactory response or complications in 8 and 8 patients, respectively, and on account of remission in 3. In 31 patients the treatment has been continued for 20 to 52 months; out of these only two patients were capable of work prior to institution of treatment as compared to 16 at the time of the present analysis.In 19 of the patients the adrenal cortical function was assessed by means of the 17-ketosteroid excretion after ACTH stimulation during the cortisone therapy. The ACTH test was performed after uninterrupted treatment for 9 to 41 months, averaging 27 months with 62.5 to 75 mg. of cortisone daily. A significant increase in 17-ketosteroid excretion was found in all cases. The average increase amounted to 420 per cent of the excretion during cortisone therapy and 250 per cent of the pre-treatment value.
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