Treatment of Recurrent Primary Cutaneous Mucinous Carcinoma of the Eyelid with Modified Wide Local Excision.

Stephanie M Tillit,John T Livecchi,Eric J Grieser,Siva S R Iyer,Maurizio Battaglia Parodi

doi:10.1155/2020/6668640

Stephanie M Tillit, John T Livecchi + Show 3 more

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https://doi.org/10.1155/2020/6668640

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Abstract

Primary cutaneous mucinous carcinoma (PCMC) is a rare, low-grade malignant neoplasm of the sweat gland, whose history has been controversial regarding eccrine versus apocrine origin. This case report describes a 53-year-old male who presented to the University of Florida, Gainesville, ophthalmology clinic and was referred to the oculoplastics service with a painless, subcentimeter mass on the lateral right upper eyelid including the canthus, consistent with recurrent primary cutaneous mucinous carcinoma of the eyelid. Four years prior, the patient had undergone excisional biopsy of the lesion in a clinic, which revealed residual tumor, but the patient deferred further surgery at the time. The patient underwent surgical excision of the mass with reconstruction without operative complications and with negative surgical margins. PCMC is difficult to diagnose clinically due to its rarity and requires a histopathological examination for confirmation of the diagnosis. This report presents the first case in the literature of primary cutaneous mucinous carcinoma in a patient with human immunodeficiency virus (HIV). With this case report, we aim to raise awareness of primary cutaneous mucinous carcinoma as a potential part of the differential diagnosis for malignant eyelid lesions, including those present in patients with HIV.

Highlights

Carcinomas of the sweat gland are known to be rare malignancies with locally aggressive features and high rates of recurrence [1]
In the age of combination antiretroviral therapy, patients with human immunodeficiency virus (HIV) have a decreased incidence of AIDS-defining cancers; the same cannot be said about melanoma and nonmelanoma skin cancers [12]
In this patient with a non-AIDS-defining cancer, the first reported in the literature with Primary cutaneous mucinous carcinoma (PCMC), the lack of a standard of care regarding management of this lesion is evident

Summary

Introduction

Carcinomas of the sweat gland are known to be rare malignancies with locally aggressive features and high rates of recurrence [1] These have been traditionally subdivided into the groups of eccrine, apocrine, mixed origin (eccrine and apocrine) and other unclassifiable sweat gland tumors [1]. Primary cutaneous mucinous carcinomas (PCMCs) may resemble mucinous carcinomas found elsewhere in the body (e.g., breast, lung, gastrointestinal-type tumors) [2]. We report the case of a 53-year-old male with recurrent primary cutaneous mucinous carcinoma of the right upper eyelid, including diagnosis, management, and follow-up. This is the first case of PCMC in a patient with human immunodeficiency virus (HIV) reported in the literature

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