Abstract
This study aimed to investigate the clinical characteristics and the treatment principles and methods of recurrent epileptic seizures in patients with neurological disorders. A retrospective analysis was performed of the clinical data, treatment methods and results in 13 patients with recurrent epileptic seizures attending the neurosurgery department. Of the 13 patients, 10 had a history of epilepsy, 9 had organic frontal lobe brain lesions and 11 exhibited frontal lobe epilepsy. The causes of the epileptic seizure aggravation included drug withdrawal, dose reduction and dressing change (5 cases). The epileptic seizure types included partial and secondary full seizures and the seizure frequency ranged from 1 seizure/3 min to 1 seizure/several h. Following combined therapy with multiple anti-epileptic drugs (AEDs), including oral administration and injection, the epilepsy was controlled. The addition of orally administered levetiracetam improved the treatment efficiency. In cases of recurrent epileptic seizures in patients with neurological disorders, the combined administration of AEDs should be conducted with doses higher than the conventional initial dose to control the epileptic seizures as rapidly as possible.
Highlights
Epilepsy is a common disease of the nervous system and domestic epidemiology surveys show that its incidence rate is 0.4‐0.7%
The treatment principle for anti‐epileptic drugs (AEDs) is to select the correct AED according to the epileptic seizure type and epileptic syndrome classification [5,6]
The present study describes the clinical characteristics and treatment methods of 13 patients with recurrent epileptic seizures treated between January 2011 and June 2012
Summary
Epilepsy is a common disease of the nervous system and domestic epidemiology surveys show that its incidence rate is 0.4‐0.7%. Certain neurological disorders are frequently complicated with epilepsy, including cerebral tumors, arteriovenous malformation, cavernous hemangioma, craniocerebral injury and cerebral cortical dysplasia. 30-40% are complicated with epilepsy [1,2] and the epilepsy. The treatment principle for anti‐epileptic drugs (AEDs) is to select the correct AED according to the epileptic seizure type and epileptic syndrome classification [5,6]. In cases where the second monotherapy does not control the seizures, combined therapy is used [7,8]. To relieve or reduce the adverse reactions or side effects of AEDs, a small dose of AED is used initially and the dose is gradually increased once every 1 or 2 weeks. For certain AEDs, 4 to 8 weeks are required to reach the effective dose [9]
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