Abstract
Progressive multifocal leukoencephalopathy (PML) is a multifocal demyelinating brain disorder caused by reactivation of a previously acquired JC virus (JCV) infection under immunosuppressive conditions. PML is most commonly associated with a Human immunodeficiency virus (HIV) infection and treatment of multiple sclerosis with Natalizumab, however PML rarely occurs with other conditions such as autoimmune diseases and malignancies [1,2]. Recently, cases of PML with idiopathic CD4+ lymphocytopenia (ICL) unaccompanied by other immunodeficiency have been reported [3,4].
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