Abstract
Primary immunodeficiencies are characterized by recurrent or prolonged infections associated with growth retardation, infections by specific microorganisms or by low virulence germs, inappropriate response to the antibiotics used, a high risk of complications and hospitalization and severe vaccine complications. The evaluation of immunological status is essential for the diagnosis of these diseases. Immunoglobulin replacement therapy is the best option for most antibody deficiencies and for some diseases that do not belong to this group, like hyper IgM syndrome, immunodeficiency with thymoma and severe combined immunodeficiency. This therapy is a safe procedure that induces dramatic positive changes in the clinical outcome of patients who carry antibody defects. An early diagnosis of primary immunodeficiencies is essential so that therapeutic measures may be taken quickly, such as the use of immunoglobulin when properly indicated, reducing the risks of death and complications
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