Treatment of primary central nervous system lymphoma

Abstract

As a kind of rare central nervous system malignant tumor, primary central nervous system lymphoma (PCNSL) has poor prognosis, and the main treatment include surgery, radiotherapy and chemothe-rapy. Stereotactic biopsy has become a routine diagnostic method of PCNSL, because of which has the advantage of minimally invasive and convenient. Whole brain radiotherapy is a standardized treatment method for the multifocal PCNSL, which can delay the progress of tumor in a short term. The therapeutic regimen based on high dose methotrexate leads to significant changes in the PCNSL treatment and it has become an effective treatment measure. Effective comprehensive treatment is the key to extending survival time and improving the quality of life for the patients with PCNSL. Key words: Lymphoma; Central nervous system neoplasms; Radiotherapy; Drug therapy; Methotrexate