Abstract
Traumatic brain injury frequently is complicated by chronic headache which may have features of either chronic migraine (CM) or chronic tension-type headache (CTTH). We currently lack any evidence-based prophylactic therapy for persistent post-traumatic headache. In this study we assessed the efficacy, safety and tolerability of onabotulinumtoxinA in treating patients with persistent post-traumatic headache and stratified patients according to the clinical phenotype of their headache disorder (ie, CM vs CTTH).
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