Abstract
The systemic approach to acne is concerned almost entirely with the use of gonadal hormone preparations. Replacement therapy with estrogens is directed at overcoming the tendency toward an increase in androgenic function. Evidence is accumulating that good to excellent control of acne eruptions may be achieved when estrogens are given to women with lesions which exhibit premenstrual exacerbations (1-7). Where severe or intractable cases of acne occur in men, estrogen therapy also can be advantageous (2, 4). The complexities of the endocrinologie aspects of acne and of its treatment, as well as the multiple etiologic factors that contribute to the disorder, account for the failures that have been reported with estrogen therapy.
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