Abstract
Purpose: The aim of this study was the clinical testing of the paste with the antifungal drug "Narine" as a temporary therapeutic dressing (bandage) for endodontic treatment of chronic apical periodontitis. Material and Methods: A total of 74 patients with сhronic apical periodontitis were selected for the study. All patients underwent a thorough clinical and microbiological examination according to the generally accepted scheme. Periapical radiographs were taken to monitor treatment. Patients were divided into 2 groups to evaluate the effectiveness of using a probiotic for endodontic therapy of chronic periapical periodontitis. Group I included 54 patients with whom the composition of the paste was used as an antibacterial and antifungal agent, based on the previously obtained positive results of their physicochemical properties: zinc oxide (ZnO) - 2,5 parts, antifungal preparation - 1.0 part ("Narine"), eugenol (clove oil) - 1 part, which was left in the root canal for 7 days, followed by filling with zinc-eugenol paste; group II included 20 patients, whose root canals were treated according to the described method, followed by filling a sealant paste based on zinc-eugenol paste (without an antifungal component). The difference between the groups was that the main group was treated with temporary healing paste. Results: The obtained results show that the antifungal drugs fluconazole, nystatin, "Narine" have antibacterial activity against Staphylolococcus aureus, Escherichia coli, Streptococcus Pseudomonas. Taking into account the beneficial effect on the periapical tissues and the obtained data of laboratory studies allowed us to use the above mentioned drugs in the treatment of root canals and subsequent obturation with their introduction into the sealer (a patent for the invention of material for filling root canals N 3426A, dated 18.01.2021 was received). Conclusion: Proposed Temporary endodontic paste is an effective addition to the traditional therapy of chronic apical periodontitis and is recommended for its use in endodontics.
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