Abstract
THERE appears to be little doubt that the fundamental factor in the production of peptic ulcer is the gastric juice, and there is an increasing body of evidence which suggests that it is the hydrochloric acid of the gastric secretion which is the element concerned. The gastric juice does not normally digest the stomach because it is buffered by the food and also by swallowed saliva, the secretion of the alkaline glands of the antrum and cardia and the regurgitation of duodenal secretion. The danger period occurs when the stomach is empty of food and especially during the hours of sleep. It is probable that patients who suffer from gastric or duodenal ulcer are the subjects of a derangement of gastric secretion, probably resulting from a functional nervous cause, as a result of which secretion of gastric juice is more profuse during the interdigestive periods than in the normal subject. In the normal person secretion during the
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