Abstract
Goldberger and Sebrell1 found that liver extract fed to dogs in large amounts either prevented or retarded the development of blacktongue (a disease which they consider analogous to pellagra of human beings). Boggs and Padgett2 stressed the curative value of liver (not liver extract) in pellagra and Smith and Ruffin3 stated that large amounts of liver extract by mouth were efficacious in treating the disease. Ramsdell and Magness4 in a preliminary study on the effects of intramuscular liver extract on the course of pellagrins, gave small daily doses and at the same time allowed the patients a highly nutritious diet. They felt that the intramuscular administration of liver extract resulted in clinical improvement but stated the patients were not given a basic diet. Since many pellagrins have severe oral lesions and refuse to eat, it seemed worthwhile to determine the therapeutic efficacy of intravenous liver extract under controlled experimental conditions.Six patients with the classical skin and oral lesi...
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